Protein Details: Aquaporin-0

Protein ID

ICDB_Pro_1111

Protein Name

Aquaporin-0

Gene Name

MIP; AQP0

Organism

Cavia porcellus (Guinea pig)

Length

263 amino acids

AlphaFoldDB

AF--F1-model_v4.pdb

Function

Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity).

Sequence

MWELRSASFWRAIFAEFFATLFYVFFGLGASLRWAPGPLHVLQVALAFGLALAXLVQTVGHISGAHVNPAVTFXFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHAGVSVXQATTVEIFLTLQFVLCIFATYDERRNGRLGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSVSERLSILKGTRPSDNNGQPEGTGEPVELKTQAL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 149: "Important for water channel gating"; SITE 246: "Interaction with BFSP1"; SITE 250: "interaction with BFSP1";